Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model

Exploring the role of EMT in ovarian cancer progression using a multiscale mathematical model

Blog Article

Abstract Epithelial-to-mesenchymal transition (EMT) plays a key role in the progression of cancer tumours, significantly reducing the success of treatment.EMT occurs when a cell undergoes phenotypical changes, resulting in enhanced drug resistance, higher cell plasticity, and increased metastatic abilities.Here, we employ a Hose 3D agent-based multiscale modelling framework using PhysiCell to explore the role of EMT over time in two cell lines, OVCAR-3 and SKOV-3.This approach allows us to investigate the spatiotemporal progression of ovarian cancer and the impacts of the conditions in the microenvironment.OVCAR-3 and SKOV-3 cell lines possess highly contrasting tumour layouts, allowing a wide range of different tumour dynamics and morphologies to be tested and studied.

Along with performing sensitivity analysis on the model, simulation results capture the biological observations and trends VITAMIN B-6 250 MG seen in tumour growth and development, thus helping to obtain further insights into OVCAR-3 and SKOV-3 cell line dynamics.